Unknown

Dataset Information

0

Local anaesthetic systemic toxicity following oral ingestion in a child: Revisiting dibucaine.


ABSTRACT: Dibucaine, a potent and toxic local anaesthetic, although currently withdrawn by the United States Food and Drug Administration for use as a spinal anaesthetic, continues to remain available in many over-the-counter topical formulations. Systemic toxicity following oral ingestion of local anaesthetics is rare. We report a case of accidental ingestion of dibucaine (ear drops) in a 7-year-old child who developed diplopia, giddiness, ventricular premature contractions and a right bundle branch block. We also present a brief discussion on the pharmacologic and toxicity profile of dibucaine, the Naranjo algorithm for assessing causality in case of adverse drug reactions and a review of current guidelines on the management of local anaesthetic systemic toxicity.

SUBMITTER: Dias R 

PROVIDER: S-EPMC5530745 | biostudies-other | 2017 Jul

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC4179566 | biostudies-literature
| S-EPMC6086754 | biostudies-literature
| S-EPMC9237992 | biostudies-literature
| S-EPMC4047767 | biostudies-literature
2023-11-08 | GSE221134 | GEO
| S-EPMC6764423 | biostudies-literature
| S-EPMC7614168 | biostudies-literature
| S-EPMC4816370 | biostudies-other
2014-11-24 | E-MTAB-3063 | biostudies-arrayexpress
| S-EPMC8394799 | biostudies-literature