Ontology highlight
ABSTRACT:
SUBMITTER: Kopec AK
PROVIDER: S-EPMC5531415 | biostudies-other | 2017 Aug
REPOSITORIES: biostudies-other
Kopec Anna K AK Abrahams Sara R SR Thornton Sherry S Palumbo Joseph S JS Mullins Eric S ES Divanovic Senad S Weiler Hartmut H Owens A Phillip AP Mackman Nigel N Goss Ashley A van Ryn Joanne J Luyendyk James P JP Flick Matthew J MJ
The Journal of clinical investigation 20170724 8
Obesity promotes a chronic inflammatory and hypercoagulable state that drives cardiovascular disease, type 2 diabetes, fatty liver disease, and several cancers. Elevated thrombin activity underlies obesity-linked thromboembolic events, but the mechanistic links between the thrombin/fibrin(ogen) axis and obesity-associated pathologies are incompletely understood. In this work, immunohistochemical studies identified extravascular fibrin deposits within white adipose tissue and liver as distinct fe ...[more]