CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer.
Ontology highlight
ABSTRACT:
SUBMITTER: Bridgett S
PROVIDER: S-EPMC5531859 | biostudies-other | 2017 Jul
REPOSITORIES: biostudies-other
Publications
CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer.
Bridgett Stephen S Campbell James J Lord Christopher J CJ Ryan Colm J CJ
Cell systems 20170712 1
Genes whose function is selectively essential in the presence of cancer-associated genetic aberrations represent promising targets for the development of precision therapeutics. Here, we present CancerGD, a resource that integrates genotypic profiling with large-scale loss-of-function genetic screens in tumor cell lines to identify such genetic dependencies. CancerGD provides tools for searching, visualizing, and interpreting these genetic dependencies through the integration of functional inter ...[more]
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