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MICROSURGICAL COMPOSITE TISSUE TRANSPLANTATION: A CLINICAL TRIAL.

ABSTRACT: Twenty four patients suffering from various ailments necessitating flap cover were treated with composite tissue transplantation by microsurgical techniques from July 1992 to July 1996. There were 21 males and 3 females in the 10 to 50 years age group. Four patients were provided flap cover on the face for congenital lesions and twenty patients required flap cover for sub acute/chronic trauma. The radial artery forearm and latissimus dorsi were the most commonly used flaps in this study. Seventeen patients had excellent and four patients had acceptable cosmetic and functional results. Three flaps were lost due to vascular problems.

SUBMITTER: Sadhotra LP

PROVIDER: S-EPMC5531870 | biostudies-other | 1999 Jul

REPOSITORIES: biostudies-other

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Project description:BACKGROUND:Patients with hepatocellular carcinoma waiting for liver transplantation are commonly treated with locoregional treatments, such as TACE and ablation, to prevent tumor progression and dropout and to improve long-term outcome after transplantation. We wanted to prospectively assess feasibility of systemic antitumor treatment with sorafenib as neoadjuvant treatment for hepatocellular carcinoma while waiting for liver transplantation, evaluating tolerability, toxicity and posttransplant morbidity. We also wanted to evaluate perfusion CT parameters to assess tumor properties and response early after start of sorafenib treatment in patients with early hepatocellular carcinoma. METHODS:Twelve patients assigned for liver transplantation due to hepatocellular carcinoma, within the UCSF and who fulfilled other criteria, were included January 2012-August 2014. After baseline evaluation, sorafenib treatment was started. Treatment was evaluated by perfusion CT at 1, 4 and 12 weeks and thereafter every 8 weeks. Toxicity and quality of life was assessed at 1 and 4 weeks and every 4 weeks thereafter during treatment. Treatment was stopped when patients were prioritized on the transplantation waiting list or when intolerable side effects or tumor progress warranted other treatments. Posttransplant morbidity after 90 days was registered according to Clavien-Dindo. RESULTS:Baseline perfusion CT parameters in the tumors predicted the outcome according to RECIST/mRECIST at three months, but no change in CTp parameters was detected as a result of sorafenib. Sorafenib as neoadjuvant treatment was associated with intolerability and dose reductions. Therefore the prerequisites for evaluation of the sorafenib effect on both CT parameters and tumor response were impaired. CONCLUSIONS:This study failed to show changes in CTp parameters during sorafenib treatment. Despite the curative treatment intention, tolerability of neoadjuvant sorafenib treatment before liver transplantation was inadequate in this study. TRIAL REGISTRATION:EudraCT number: 2010-024306-36 (date 2011-04-07).

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MICROSURGICAL COMPOSITE TISSUE TRANSPLANTATION: A CLINICAL TRIAL.

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