The blalock and taussig shunt revisited.
Ontology highlight
ABSTRACT:
SUBMITTER: Kiran U
PROVIDER: S-EPMC5535574 | biostudies-other | 2017 Jul-Sep
REPOSITORIES: biostudies-other
Similar Datasets
Project description:Platypnea-orthodeoxia syndrome is a rare disease defined by dyspnea and deoxygenation, induced by an upright position, and relieved by recumbency. Causes include shunting through a patent foramen ovale and pulmonary arteriovenous malformations. A 79-year-old woman experienced 2 syncopal episodes at rest and presented at another hospital. In the emergency department, she was hypoxic, needing 6 L/min of oxygen. Her chest radiograph showed nothing unusual. Transthoracic echocardiograms with saline microcavitation evaluation were mildly positive early after agitated-saline administration, suggesting intracardiac shunting. She was then transferred to our center. Right-sided heart catheterization revealed no oximetric evidence of intracardiac shunting while the patient was supine and had a low right atrial pressure. However, her oxygen saturation dropped to 78% when she sat up. Repeat transthoracic echocardiography while sitting revealed a dramatically positive early saline microcavitation-uptake into the left side of the heart. Transesophageal echocardiograms showed a patent foramen ovale, with right-to-left shunting highly dependent upon body position. The patient underwent successful percutaneous patent foramen ovale closure, and her oxygen supplementation was suspended. In patients with unexplained or transient hypoxemia in which a cardiac cause is suspected, it is important to evaluate shunting in both the recumbent and upright positions. In this syndrome, elevated right atrial pressure is not necessary for significant right-to-left shunting. Percutaneous closure, if feasible, is first-line therapy in these patients.
| S-EPMC4894711 | biostudies-literature
Project description:Arteriogenesis is defined as the development of a collateral circulation, bypassing an arterial occlusion. We have previously demonstrated that chronically elevated fluid shear stress completely normalized blood flow in femoral artery ligated rabbits. This was realized by a surgical intervention: the creation of an arterio- venous anastomosis (shunt) between the femoral artery and the accompanying vein. The aim of this study was a gene profiling approach in order to identify differentially expressed genes during collateral growth in the shunt model when compared to pre-existent collaterals (sham).
2010-05-26 | GSE16359 | GEO
Project description:The possibility of generating neural cells from human bone marrow-derived mesenchymal stem cells by simple in vitro treatments is alluring both conceptually and practically. However, whether phenotypic modulations observed after chemical manipulation of such stem cells truly represent a genuine trans-lineage differentiation remains to be established. We have re-evaluated the effects of a frequently reported biochemical approach, based on treatment with butylated hydroxyanisole and dimethylsulphoxide, to bring about such phenotypic conversion by monitoring the morphological changes induced by the treatment in real time, by analysing the expression of phenotype-specific protein markers and by assessing the modulation of the cells’ transcriptome. Video time-lapse microscopy showed that conversion of mesenchymal stem cells to a neuron-like morphology could be reproduced in normal primary fibroblasts as well as mimicked by addition of drugs eliciting cytoskeletal collapse and disruption of focal adhesion contacts. Analysis of markers revealed that mesenchymal stem cells constitutively expressed multi-lineage traits, including several pertaining to the neural one. However, the applied “neural induction” protocol neither significantly modulated the expression of such markers, nor induced de novo translation of other neural specific proteins. Similarly, global expression profiling of over 21,000 genes demonstrated that gene transcription was poorly affected. Most strikingly, we found that the set of genes whose expression was altered by the inductive treatment did not match the set of genes found to be differentially expressed when comparing untreated mesenchymal stem cells and immature neural tissues. Conversely, by comparing these gene expression profiles with that obtained from comparisons between the same cells and an unrelated non-neural organ, such as liver, we found that the adopted “neural induction” protocol was no more effective in redirecting human mesenchymal stem cells toward a neural phenotype than toward an endodermal hepatic pathway. Keywords: Differentiation analysis
2005-08-10 | GSE2776 | GEO
Project description:Species of Pestalotiopsis occur commonly as plant pathogens, and represent a fungal group known to produce a wide range of chemically novel, diverse metabolites. In the present study, we investigated 91 Pestalotiopsis isolates from the CBS-KNAW Fungal Biodiversity Centre (CBS) culture collection. The phylogeny of the Amphisphaeriaceae was constructed based on analysis of 28S nrRNA gene (LSU) sequence data, and taxonomic changes are proposed to reflect more natural groupings. We combined morphological and DNA data, and segregated two novel genera from Pestalotiopsis, namely Neopestalotiopsis and Pseudopestalotiopsis. The three genera are easily distinguishable on the basis of their conidiogenous cells and colour of their median conidial cells. We coupled morphological and combined sequence data of internal transcribed spacer (ITS), partial ?-tubulin (TUB) and partial translation elongation factor 1-alpha (TEF) gene regions, which revealed 30 clades in Neopestalotiopsis and 43 clades in Pestalotiopsis. Based on these data, 11 new species are introduced in Neopestalotiopsis, 24 in Pestalotiopsis, and two in Pseudopestalotiopsis. Several new combinations are proposed to emend monophyly of Neopestalotiopsis, Pestalotiopsis and Pseudopestalotiopsis.
| S-EPMC4255583 | biostudies-literature
Project description:ObjectiveTo examine the references to Cinderella in medical literature.DesignAnalysis of papers published in the past 50 years that mention Cinderella.ResultsThe trend for use of Cinderella as a metaphor in medical publications is increasing exponentially. Five separate themes emerged: neglect, identity, transformation, exhaustion, and the mixed metaphor.ConclusionsThe medical use of the Cinderella fable is growing in popularity.
| S-EPMC1322262 | biostudies-literature
Project description:In comparison with previous stucture determinations of Li2PtF6, dilithium hexa-fluorido-platinate(IV) [Graudejus et al. (2000 ?). Inorg. Chem. 39, 2794-2800; Henkel & Hoppe (1968 ?). Z. Anorg. Allg. Chem. 359, 160-177], the current study revealed the Li atom to be refined with anisotropic displacement parameters, thus allowing for a higher overall precision of the model. Li2PtF6 adopts the trirutile structure type with site symmetries of 2.mm, m.mm, ..m and m.2m for the Li, Pt and the two F sites. The Pt-F distances in the slightly distorted PtF6 octa-hedron are essentially similar with 1.936?(4) and 1.942?(6)?Å, and the equatorial F-Pt-F angles range from 82.2?(2) to 97.8?(2)°. The Li-F distances in the somewhat more distorted LiF6 octa-hedron are 1.997?(15) and 2.062?(15)?Å, with equatorial F-Li-F angles ranging from 76.3?(7) to 99.71?(17)°.
| S-EPMC4158554 | biostudies-literature
Project description:A comparison of methylMiner and MethylCap, two methylation enrichment kits The main analysis include two individuals (mice) in technical duplicates from various lab/technical conditions. The results are compared with previous studies of two human samples from a number of lab/technical conditions (human data available at dbGaP: record number phs000608.v1.p1). In addition a DNA from a third mouse is used for investigations of specific alterations of the protocol.
2014-12-20 | E-GEOD-64144 | biostudies-arrayexpress
Project description:The reversed Potts shunt is designed to offload the right ventricle in severe pulmonary arterial hypertension. We present a case of bidirectional flow across a reversed Potts shunt leading to pulmonary edema, with clinical improvement after implantation of a transcatheter valve in the shunt to maintain unidirectional flow. (Level of Difficulty: Advanced.).
| S-EPMC9706157 | biostudies-literature
Project description:Capacitance limits the bandwidth of engineered and biological electrical circuits because it determines the gain-bandwidth product (GBWP). With a fixed GBWP, bandwidth can only be improved by decreasing gain. In engineered circuits, an inductance reduces this limitation through shunt peaking but no equivalent mechanism has been reported for biological circuits. We show that in blowfly photoreceptors a voltage-dependent K+ conductance, the fast delayed rectifier (FDR), produces shunt peaking thereby increasing bandwidth without reducing gain. Furthermore, the FDR's time constant is close to the value that maximizes the photoreceptor GBWP while reducing distortion associated with the creation of a wide-band filter. Using a model of the honeybee drone photoreceptor, we also show that a voltage-dependent Na+ conductance can produce shunt peaking. We argue that shunt peaking may be widespread in graded neurons and dendrites.
| S-EPMC5134022 | biostudies-literature