Mechanical regulation of cardiac fibroblast profibrotic phenotypes.
Ontology highlight
ABSTRACT:
SUBMITTER: Herum KM
PROVIDER: S-EPMC5541838 | biostudies-other | 2017 Jul
REPOSITORIES: biostudies-other
Publications
Mechanical regulation of cardiac fibroblast profibrotic phenotypes.
Herum Kate M KM Choppe Jonas J Kumar Aditya A Engler Adam J AJ McCulloch Andrew D AD
Molecular biology of the cell 20170503 14
Cardiac fibrosis is a serious condition currently lacking effective treatments. It occurs as a result of cardiac fibroblast (CFB) activation and differentiation into myofibroblasts, characterized by proliferation, extracellular matrix (ECM) production and stiffening, and contraction due to the expression of smooth muscle α-actin. The mechanical properties of myocardium change regionally and over time after myocardial infarction (MI). Although mechanical cues are known to activate CFBs, it is unc ...[more]
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