Ontology highlight
ABSTRACT:
SUBMITTER: Garcia-Santos D
PROVIDER: S-EPMC5541866 | biostudies-other | 2017 Aug
REPOSITORIES: biostudies-other
Garcia-Santos Daniel D Schranzhofer Matthias M Bergeron Richard R Sheftel Alex D AD Ponka Prem P
Haematologica 20170511 8
Vertebrate heme synthesis requires three substrates: succinyl-CoA, which regenerates in the tricarboxylic acid cycle, iron and glycine. For each heme molecule synthesized, one atom of iron and eight molecules of glycine are needed. Inadequate delivery of iron to immature erythroid cells leads to a decreased production of heme, but virtually nothing is known about the consequence of an insufficient supply of extracellular glycine on the process of hemoglobinization. To address this issue, we expl ...[more]