Ontology highlight
ABSTRACT:
SUBMITTER: Sinclair LI
PROVIDER: S-EPMC5545905 | biostudies-other | 2017
REPOSITORIES: biostudies-other
Journal of Alzheimer's disease : JAD 20170101 3
<h4>Background</h4>Possession of APOEɛ4 is a strong risk factor for late-onset Alzheimer's disease and is associated with loss of synaptic proteins in the elderly even in the absence of Alzheimer's disease.<h4>Objective</h4>We hypothesized that ɛ4 allele possession in non-demented adults aged under-75 would also be associated with alterations in the levels of synaptic proteins.<h4>Methods</h4>We measured synaptophysin, PSD95, drebrin, SNAP-25, and septin 7 by ELISA in hippocampus and superior te ...[more]