Deregulation of the non-coding genome in leukemia.

ABSTRACT: Methodological advances that allow deeper characterization of non-coding elements in the genome have started to reveal the full spectrum of deregulation in cancer. We generated an inducible cell model to track transcriptional changes after induction of a well-known leukemia-inducing fusion gene, ETV6-RUNX1. Our data revealed widespread transcriptional alterations outside coding elements in the genome. This adds to the growing list of various alterations in the non-coding genome in cancer and pinpoints their role in diseased cellular state.

SUBMITTER: Teppo S 

PROVIDER: S-EPMC5546539 | biostudies-other | 2017 Jul

REPOSITORIES: biostudies-other