Deregulation of the non-coding genome in leukemia.
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ABSTRACT: Methodological advances that allow deeper characterization of non-coding elements in the genome have started to reveal the full spectrum of deregulation in cancer. We generated an inducible cell model to track transcriptional changes after induction of a well-known leukemia-inducing fusion gene, ETV6-RUNX1. Our data revealed widespread transcriptional alterations outside coding elements in the genome. This adds to the growing list of various alterations in the non-coding genome in cancer and pinpoints their role in diseased cellular state.
SUBMITTER: Teppo S
PROVIDER: S-EPMC5546539 | biostudies-other | 2017 Jul
REPOSITORIES: biostudies-other
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