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Secure searching of biomarkers through hybrid homomorphic encryption scheme.

ABSTRACT: As genome sequencing technology develops rapidly, there has lately been an increasing need to keep genomic data secure even when stored in the cloud and still used for research. We are interested in designing a protocol for the secure outsourcing matching problem on encrypted data.We propose an efficient method to securely search a matching position with the query data and extract some information at the position. After decryption, only a small amount of comparisons with the query information should be performed in plaintext state. We apply this method to find a set of biomarkers in encrypted genomes. The important feature of our method is to encode a genomic database as a single element of polynomial ring.Since our method requires a single homomorphic multiplication of hybrid scheme for query computation, it has the advantage over the previous methods in parameter size, computation complexity, and communication cost. In particular, the extraction procedure not only prevents leakage of database information that has not been queried by user but also reduces the communication cost by half. We evaluate the performance of our method and verify that the computation on large-scale personal data can be securely and practically outsourced to a cloud environment during data analysis. It takes about 3.9 s to search-and-extract the reference and alternate sequences at the queried position in a database of size 4M.Our solution for finding a set of biomarkers in DNA sequences shows the progress of cryptographic techniques in terms of their capability can support real-world genome data analysis in a cloud environment.

SUBMITTER: Kim M

PROVIDER: S-EPMC5547457 | biostudies-other | 2017 Jul

REPOSITORIES: biostudies-other

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Project description:In heterogeneous wireless networks, the industrial Internet of Things (IIoT) is an essential contributor to increasing productivity and effectiveness. However, in various domains, such as industrial wireless scenarios, small cell domains, and vehicular ad hoc networks, an efficient and stable authentication algorithm is required (VANET). Specifically, IoT vehicles deal with vast amounts of data transmitted between VANET entities in different domains in such a large-scale environment. Also, crossing from one territory to another may have the connectivity services down for a while, leading to service interruption because it is pervasive in remote areas and places with multipath obstructions. Hence, it is vulnerable to specific attacks (e.g., replay attacks, modification attacks, man-in-the-middle attacks, and insider attacks), making the system inefficient. Also, high processing data increases the computation and communication cost, leading to an increased workload in the system. Thus, to solve the above issues, we propose an online/offline lightweight authentication scheme for the VANET cross-domain system in IIoT to improve the security and efficiency of the VANET. The proposed scheme utilizes an efficient AES-RSA algorithm to achieve integrity and confidentiality of the message. The offline joining is added to avoid remote network intrusions and the risk of network service interruptions. The proposed work includes two different significant goals to achieve first, then secure message on which the data is transmitted and efficiency in a cryptographic manner. The Burrows Abdi Needham (BAN logic) logic is used to prove that this scheme is mutually authenticated. The system's security has been tested using the well-known AVISPA tool to evaluate and verify its security formally. The results show that the proposed scheme outperforms the ID-CPPA, AAAS, and HCDA schemes by 53%, 55%, and 47% respectively in terms of computation cost, and 65%, 83%, and 40% respectively in terms of communication cost.

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Secure searching of biomarkers through hybrid homomorphic encryption scheme.

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