Pilot study into impaired judgement, self-toileting behaviour in fallers and non-fallers.
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ABSTRACT:
SUBMITTER: Chan DKY
PROVIDER: S-EPMC5549125 | biostudies-other | 2013 Sep
REPOSITORIES: biostudies-other
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Project description:BACKGROUND:Fall rates among adults with multiple sclerosis are consistently greater than 50%, but near-falls (i.e. a trip or stumble) are often undocumented. Furthermore, little is known about the circumstances surrounding fall and near-fall events. The purpose of this study was to examine the similarities and differences among non-fallers, near-fallers and fallers with multiple sclerosis, including the circumstances that surround falls and near-falls. METHODS:In a single visit, 135 multiple sclerosis participants completed the Hopkins Falls Grading Scale, a custom questionnaire investigating circumstances surrounding falls and near-falls, and performed the Timed Up and Go and Timed 25-Foot Walk tests. Mann-Whitney tests were used to examine differences between fallers, near-fallers and non-fallers. Multiple logistic regression with AIC criterion was used to examine associations of circumstances with the odds of falling vs. near-falling. Cumulative odds ordinal logistic regression was used to analyze the association between each of the walking tests and the susceptibility of the individual for falls or near-falls. RESULTS:30% of individuals reported falls, while 44% reported near-falls over a 1-year period. Non-fallers completed the walking tests more quickly than near-fallers (p < 0.0045), and fallers (p < 0.0001); near-fallers and fallers demonstrated similar motor profiles. Individuals were more likely to sustain a fall rather than a near-fall under the following circumstances: transferring outside the home (p = 0.015) and tripping over an obstacle (p = 0.025). Performing 1-second slower on the walking tests increased the odds of a history of a fall by 6-20%. CONCLUSION:Near-falls occur commonly in individuals with MS; near-fallers and fallers reported similar circumstances surrounding fall events and demonstrated similar performance on standard timed walking tests. Clinicians monitoring individuals with MS should consider evaluation of the circumstances surrounding falls in combination with quantitative walking measures to improve determination of fall risk and appropriate rehabilitation interventions.
| S-EPMC5803437 | biostudies-literature
Project description:BACKGROUND:Clinical coding is an integral part of primary care. Disease incidence studies based on primary care electronic health records (EHRs) rely on the accuracy of these codes. Current code validation methods are not appropriate for non-specific conditions and provide limited information about GPs' decision-making behaviour around coding. Qualitative methods could offer insight into decision-making behaviour around coding of patients with non-specific conditions. AIM:To investigate the decision-making behaviour of GPs when applying Read codes to non-specific clinical presentations, using Lyme disease as a case example. DESIGN & SETTING:A pilot study was undertaken, involving masked semi-structured interviews of eight GPs in the North West of England. METHOD:Semi-structured interviews were carried out based on 11 clinical cases representative of Lyme disease presentations. Discrete answers were described descriptively. Interview transcripts were analysed using a thematic approach. RESULTS:Themes underpinning GPs' coding behaviour included: GP personal and professional experience; clinical evidence; diagnostic uncertainty; professional integrity and defensive practice; and patient-sourced health information and beliefs. GPs placed Lyme disease on their differential diagnosis list for five cases; in only two cases would GPs select a Lyme disease related Read code. CONCLUSION:GPs were reluctant to code with specific diagnostic Read codes when they were presented with patients with vague or unfamiliar symptomology. This masked questionnaire methodology offers a new approach to validate incidence figures, based on Read codes of non-specific conditions. The reluctance to code poses many problems for primary care EHRs research. Further research is needed to understand what drives GPs' coding behaviour.
| S-EPMC7465576 | biostudies-literature
Project description:Wearable sensors could facilitate point of care, clinically feasible assessments of dynamic stability and associated fall risk through an assessment of single-task (ST) and dual-task (DT) walking. This study investigated gait changes between ST and DT walking and between older adult prospective fallers and non-fallers. The results were compared to a study based on retrospective fall occurrence. Seventy-five individuals (75.2 ± 6.6 years; 47 non-fallers, 28 fallers; 6 month prospective fall occurrence) walked 7.62 m under ST and DT conditions while wearing pressure-sensing insoles and accelerometers at the head, pelvis, and on both shanks. DT-induced gait changes included changes in temporal measures, centre of pressure (CoP) path stance deviations and coefficient of variation, acceleration descriptive statistics, Fast Fourier Transform (FFT) first quartile, ratio of even to odd harmonics, and maximum Lyapunov exponent. Compared to non-fallers, prospective fallers had significantly lower DT anterior?posterior CoP path stance coefficient of variation, DT head anterior?posterior FFT first quartile, ST left shank medial?lateral FFT first quartile, and ST right shank superior maximum acceleration. DT-induced gait changes were consistent regardless of faller status or when the fall occurred (retrospective or prospective). Gait differences between fallers and non-fallers were dependent on retrospective or prospective faller identification.
| S-EPMC5948604 | biostudies-literature
Project description:Impaired balance, loss of mobility and falls are major problems associated with changes in muscle in older adults. However, the extent to which muscle composition and related performance measures for different lower limb muscles are associated with falls in older individuals is unclear. This study evaluated lower limb muscle attenuation, intramuscular adipose tissue (IMAT) infiltration and muscle performance in older fallers and non-fallers.For this cross-sectional study, fifty-eight community dwelling older individuals (>65 years) were classified into fallers (n?=?15) or non-fallers (n?=?43). Computed tomography (CT) was used to determine muscle attenuation and intramuscular adipose tissue (IMAT) of multiple thigh and hip muscles. Muscle performance was assessed with isokinetic dynamometry.For both groups, Rectus Femoris showed the highest muscle attenuation and lowest IMAT infiltration, and Gluteus Maximus and Gluteus Medius/Minimus muscles had the lowest muscle attenuation and highest IMAT infiltration. Fallers exhibited lower muscle attenuation and higher IMAT infiltration than non-faller participants in most muscles, where the gluteal muscles were the most affected (p?<?0.05). Fallers also showed a lower peak hip abduction torque (p?<?0.05). There were significant associations (r?=?0.31 to 0.53) between joint torques and muscle composition, with the strongest associations between Gluteus Medius/Minimus and hip abduction strength.While fallers were generally differentiated from non-fallers by muscle composition, the most affected muscles were the proximal gluteal muscles of the hip joint accompanied by lower hip abduction strength, which may contribute to impaired balance function and increased risk for falls.
| S-EPMC4101852 | biostudies-other
Project description:Non-suicidal self-injury (NSSI) is prevalent in adolescence and is associated with increased risk for a variety of subsequent negative mental health outcomes, necessitating an evidence-based preventive approach. This pilot study examines the potential iatrogenic effects and feasibility of an evidence-based school program for the prevention of NSSI. Differences are examined between a general in-classroom prevention program (Happyles) and this program combined with a 1-h in-classroom psychoeducation module on NSSI (HappylesPLUS) in terms of primary (e.g., delay in NSSI onset and decrease in NSSI frequency, urges, probability of future engagement) and secondary outcomes (e.g., psychological distress, emotion regulation, help-seeking, and stigma) using a mixed-method design. A total of 651 secundary school pupils (Mage = 12.85 years; 49.8% female versus 50.2% male) were assigned to the Happyles program and HappylesPLUS. Participants filled out validated self-report questionnaires pre (T0) and post (T1, 6 weeks after T0) the school prevention program, including the Youth Outcome Questionnaire (YOQ), the Brief Non-Suicidal Self-Injury Assessment Test (BNSSI-AT), the Difficulties in Emotion Regulation Scale (DERS), the Attitudes Toward Seeking Professional Psychological Help Scale-Short Form (ATSPPH-SF), and the Peer Mental Health Stigmatization Scale (PMHSS). Qualitative semi-structured interviews (at T2,6 weeks after T1) were conducted with participants with and without a history of NSSI. Overall, results show no iatrogenic effects of the NSSI-focused psychoeducation module. In terms of our primary outcome, both groups reported a reduced likelihood of future NSSI engagement from T0 to T1. Regarding secondary outcome measures, we also observed increased emotional awareness in both groups. The qualitative data suggest that the addition of the NSSI-specific module to the Happyles program may have direct benefits to some students with lived experience, such as increased help-seeking behavior for NSSI. Findings of this pilot study show that incorporating NSSI-specific modules into evidence-based school prevention programs is feasible and does not lead to iatrogenic effects. Future work is needed to evaluate the potential (longer-term) benefits of incorporating NSSI-focused modules to evidence-based mental health programs in the prevention of NSSI.
| S-EPMC7298560 | biostudies-literature
Project description:1) To compare the ability of functional mobility and balance assessments in discriminating fallers from non-fallers and recurrent fallers from those with fewer or no falls. 2) To compare the discriminatory accuracy of cut-off scores specific to this study sample with that of cut-off scores proposed in the literature for community-dwelling older adults.In a sample of 39 ambulatory older adults living independently in the community, fallers were identified on the basis of number of falls in the past year. Seven functional tests of mobility and balance were used to identify fallers and recurrent fallers on the basis of their fall history.Discrimination of fallers from non-fallers was poor: Only a high-level balance assessment significantly discriminated these groups (p=0.0498, area under the curve [AUC]=0.68). Four assessments significantly discriminated recurrent fallers from those with fewer or no falls (ps=0.006-0.009), but their discriminatory powers were not significantly different from one another (AUCs=0.77-0.80, p>0.05). For two assessments, cutoff scores based on the study sample enhanced discriminatory accuracy relative to the literature-based cutoff scores.To improve fall prediction for ambulatory community-dwelling older adults, future prospective studies should consider including high-level mobility and balance assessments and targeting cutoff scores to the level of function of this relatively high-functioning population.
| S-EPMC4407130 | biostudies-literature
Project description:BackgroundThe purpose of this study was to determine the reliability of a forceplate postural balance protocol in a group of elderly fallers and non-fallers. The measurements were tested in single and dual-task conditions, with and without vision.Methods37 elderly (mean age 73 +/- 6 years) community-dwellers were included in this study. All were tested in a single (two-legged stance) and in a dual-task (two-legged stance while counting backwards aloud in steps of 7's) condition, with and without vision. A forceplate was used for registering postural variables: the maximal and the root-mean-square amplitude in medio-lateral (Max-ML, RMS-ML) and antero-posterior (Max-AP, RMS-AP) direction, mean velocity (MV), and the area of the 95% confidence ellipse (AoE). Reliability of the test protocol was expressed with intraclass correlation coefficients (ICC), with 95% limits of agreement (LoA), and with the smallest detectable difference (SDD).ResultsThe ICCs for inter-rater reliability and test-retest reliability of the balance variables were r = 0.70-0.89. For the variables Max-AP and RMS-AP the ICCs were r = 0.52-0.74. The SDD values were for variable Max-ML and Max-AP between 0.37 cm and 0.83 cm, for MV between 0.48 cm/s and 1.2 cm/s and for AoE between 1.48 cm2 and 3.75 cm2. The LoA analysis by Bland-Altman plots showed no systematic differences between test-retest measurements.ConclusionThe study showed good reliability results for group assessment and no systematic errors of the measurement protocol in measuring postural balance in the elderly in a single-task and dual-task condition.
| S-EPMC2614424 | biostudies-literature
Project description:BACKGROUND:Falls reflect sentinel events in older adults, with significant negative consequences. Although fall risk factors have been identified as intrinsic (e.g., muscle weakness, balance problems) and extrinsic (e.g., home hazards), most prevention programs target only intrinsic factors. We present the rationale and design of a home-based multicomponent fall prevention program-the LIVE LiFE program-for community-living older adults. The program adapts and expands the successful Lifestyle Intervention Functional Exercise (LiFE) program by adding home safety, vision contrast screening, and medication review. The specific aims of the study are to (1) adapt the LiFE program to a US context and expand it into a multicomponent program (LIVE LiFE) addressing intrinsic and extrinsic fall risks, (2) examine feasibility and acceptability, and (3) estimate program impact on multiple outcome measures to prepare for an efficacy trial. METHODS:The study involves two phases: an open-label pilot, followed by a two-group, single-blinded randomized pilot trial. Eligible participants are community-living adults 70+ years reporting at least one injurious fall or two non-injurious falls in the previous year. Participants are randomized in a 2:1 ratio to the program group (LIVE LiFE, n?=?25) or the control group (written fall risk assessment, n?=?12). The open-label pilot participants (n?=?3) receive the program without randomization and are assessed based on their experience, resulting in a stronger emphasis on the participant's personal goals being integrated into LIVE LiFE. Fall risk and balance outcomes are assessed by the Timed Up and Go and the 4-Stage Balance Test at 16?weeks. Additional outcomes are incidence of falls and near falls, falls efficacy, fear of falling, number of home hazards, and medications assessed at 16?weeks. Incidence of falls and near falls, program adherence, and satisfaction are assessed again at 32?weeks. DISCUSSION:By expanding and adapting the evidence-based LiFE program, our study will help us understand the feasibility of conducting a multicomponent program and estimate its impact on multiple outcome measures. This will support moving forward with an efficacy trial of the LIVE LiFE program for older adults who are at risk of falling. TRIAL REGISTRATION:ClinicalTrials.gov, NCT03351413 . Registered on 22 November 2017.
| S-EPMC6318957 | biostudies-literature
Project description:INTRODUCTION:Compared to controlled laboratory settings, the real world is highly distracting with constant demands on visual attention to avoid hazards and falling. Fall-risk assessments do not adequately take into account the potential role of everyday distractions and environmental hazards. The purpose of this project was to identify the effect of the environment on gait and gaze behavior during walking in older adult fallers relative to non-fallers. METHODS:Thirteen older adult fallers (76.8±9.4 years, 3.2±2.3 falls in last year) and 13 age-matched non-fallers (78.3±7.3 years, 0 falls in last year) participated. Participants walked in a real-world and lab setting while gait and gaze were recorded. Gait variables were stride length variability, stride duration variability, and stride velocity. Gaze was analyzed for percentage of time fixating and average fixation duration coded across 6 areas of interest (AOIs) in the visual surroundings. RESULTS:Non-fallers walked faster than fallers, but there were no other group or environment effects on gait. For gaze behavior, fallers had shorter fixation durations on the near environment than non-fallers, but only in the real world. In the real world relative to the lab, fallers decreased fixation durations on the near environment but increased durations on near people. In the real world, participants spent a greater proportion of time fixating on people than on the walking path or the near environment compared to the lab. After adjusting for baseline gait speed, fallers had shorter fixation durations than non-fallers in both environments. CONCLUSIONS:Our results indicate that in a busy environment, older adults concentrate most of their overt visual attention on people when navigating their walking path. Fallers in particular focus longer on people near to them and have overall shorter fixations than non-fallers. Visual focus while walking in a busy environment should be further explored as a fall-risk factor.
| S-EPMC7083306 | biostudies-literature
Project description:Several series of structurally flexible, non-preorganized oligoamides with carboxylic acid, hydride, N-propargyl amide and N-propyl amide end groups were synthesized and characterized. They were found to be strong organogelators for aromatic solvents. Both the number and density of the amide units, and the nature of the end group were found to influence the gel strength as well as the kinetics of gel formation. Oligomers with a higher number and density of amide units were found to form stronger gels. Rather unexpectedly, a slight change of the end group could significantly affect the enthalpy and entropy of formation of the resulting self-assembly. Oligomers with the N-propargyl amide end group were found to be kinetically trapped in the melted state, which devoid them of forming crystalline zone upon cooling. On the other hand, the corresponding saturated N-propyl amide analog did not show the same effect. Upon mixing of these oligomers, narcissistic self-sorting could be observed in both the wet gel and xerogel states if (i) the difference in the number of amide units is greater than one or (ii) the amide unit densities are different. A semi-quantitative assessment of the extent of self-sorting could be achieved by constructing the corresponding phase diagram of the mixed gel systems. It is concluded that narcissistic self-sorting does not just prevail in mixtures making up of structurally different molecules, but appears to be fairly general even in mixtures of structurally similar molecular homologs.
| S-EPMC6457331 | biostudies-literature