Defining and Targeting the Oncogenic Drivers of Neuroendocrine Prostate Cancer.
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ABSTRACT: In this issue of Cancer Cell, Lee and colleagues (2016) define the biologic role of MYCN in promoting prostate tumorigenesis and development of a neuroendocrine phenotype. This has important implications for the clinical management of neuroendocrine prostate cancer as Aurora A kinase inhibitors promoting N-Myc destabilization progress in the clinic.
SUBMITTER: Carver BS
PROVIDER: S-EPMC5550814 | biostudies-other | 2016 Apr
REPOSITORIES: biostudies-other
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