Ontology highlight
ABSTRACT:
SUBMITTER: Cheng L
PROVIDER: S-EPMC5550856 | biostudies-other | 2017 Jul
REPOSITORIES: biostudies-other
Cheng Li L Zhu Yahui Y Han Han H Han Han H Zhang Qiang Q Cui Kaisa K Shen Hongxing H Zhang Jinxiang J Yan Jun J Prochownik Edward E Li Youjun Y
Cell death & disease 20170713 7
miRNAs are involved in many physiologic and disease processes by virtue of degrading specific mRNAs or inhibiting their translation. miR-148a has been implicated in the control of tumor growth and cholesterol and triglyceride homeostasis using in vitro or in vivo gene expression- and silencing-based approaches. Here miR-148a knockout (KO) mice were used to investigate the intrinsic role of miR-148a in liver physiology and hepatocarcinogenesis in mice. miR-148a downregulation was found to be corr ...[more]