Unknown

Dataset Information

0

Expression of galectin-3 correlates with apoptosis in pituitary adenoma cells.


ABSTRACT: To investigate the expressions of Galectin-3 (Gal-3), Bcl-2 and Bax in human pituitary adenomas, and to explore the interrelation among them.RT-PCR and immunohistochemistry were applied to detect the mRNA and protein expressions of Gal-3, Bcl-2 and Bax in surgically excised human pituitary adenoma tissues, including invasive and non-invasive pituitary adenomas, and the correlation analysis was performed.The Gal-3 and Bcl-2 expressions in the invasive pituitary group were significantly higher than those in the non-invasive group, and the expression of Bax had no significant difference between the two groups. Pearsonos correlation analyses showed that the Gal-3 expression was positively correlated with Bcl-2, but was not correlated with Bax, which was inversely correlated with expression of Bcl-2.Gal-3 may function through a cell death inhibition pathway involving Bcl-2 to enhance cell proliferation, which result in the invasive growth of pituitary adenoma. These results indicate that Gal-3 has an important role in pituitary tumor cell proliferation and may serves as a possible therapeutic target in treatment of pituitary tumors.

SUBMITTER: Huang CX 

PROVIDER: S-EPMC5552520 | biostudies-other | 2008 Feb

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC6083820 | biostudies-literature
| S-EPMC1606586 | biostudies-literature
2020-07-09 | GSE101012 | GEO
| S-EPMC3978815 | biostudies-literature
| S-EPMC4214395 | biostudies-literature
| S-EPMC1866928 | biostudies-literature
| S-EPMC7044184 | biostudies-literature
2020-01-13 | E-MTAB-7768 | biostudies-arrayexpress
| S-EPMC5347795 | biostudies-literature
| S-EPMC2927870 | biostudies-literature