Ontology highlight
ABSTRACT:
SUBMITTER: Hernandez-Ochoa B
PROVIDER: S-EPMC5552691 | biostudies-other | 2017 Aug
REPOSITORIES: biostudies-other
Hernández-Ochoa B B Navarrete-Vázquez G G Nava-Zuazo C C Castillo-Villanueva A A Méndez S T ST Torres-Arroyo A A Gómez-Manzo S S Marcial-Quino J J Ponce-Macotela M M Rufino-González Y Y Martínez-Gordillo M M Palencia-Hernández G G Esturau-Escofet N N Calderon-Jaimes E E Oria-Hernández J J Reyes-Vivas H H
Scientific reports 20170810 1
Giardiasis is a worldwide parasitic disease that affects mainly children and immunosuppressed people. Side effects and the emergence of resistance over current used drugs make imperative looking for new antiparasitics through discovering of new biological targets and designing of novel drugs. Recently, it has determined that gastric proton-pump inhibitors (PPI) have anti-giardiasic activity. The glycolytic enzyme, triosephosphate isomerase (GlTIM), is one of its potential targets. Therefore, we ...[more]