Ontology highlight
ABSTRACT:
SUBMITTER: Rena G
PROVIDER: S-EPMC5552828 | biostudies-other | 2017 Sep
REPOSITORIES: biostudies-other
Rena Graham G Hardie D Grahame DG Pearson Ewan R ER
Diabetologia 20170803 9
Metformin is a widely-used drug that results in clear benefits in relation to glucose metabolism and diabetes-related complications. The mechanisms underlying these benefits are complex and still not fully understood. Physiologically, metformin has been shown to reduce hepatic glucose production, yet not all of its effects can be explained by this mechanism and there is increasing evidence of a key role for the gut. At the molecular level the findings vary depending on the doses of metformin use ...[more]