Ontology highlight
ABSTRACT:
SUBMITTER: Lainson JC
PROVIDER: S-EPMC5554890 | biostudies-other | 2017 Aug
REPOSITORIES: biostudies-other
Lainson John C JC Daly Seth M SM Triplett Kathleen K Johnston Stephen Albert SA Hall Pamela R PR Diehnelt Chris W CW
ACS medicinal chemistry letters 20170707 8
One proposed solution to the crisis of antimicrobial resistant (AMR) infections is the development of molecules that potentiate the activity of antibiotics for AMR bacteria, such as methicillin-resistant <i>Staphylococcus aureus</i> (MRSA). Rather than develop broad spectrum compounds, we developed a peptide that could potentiate the activity of a narrow spectrum antibiotic, oxacillin. In this way, the combination treatment could narrowly target the resistant pathogen and limit impact on host fl ...[more]