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Following the fate of endocytosed fibrils.


ABSTRACT: Cell-to-cell transmission of intracellular protein aggregates is considered a central event in many neurodegenerative diseases, but little is known about the underlying molecular mechanisms. A new study employs fluorescence quenching to examine the fate of α-synuclein, a key molecule in the pathology of Parkinson's disease and related disorders, in primary cultured neurons, finding that endocytosis and lysosomal processing of exogenous fibrils may explain the transmission of α-synuclein pathology.

SUBMITTER: Hasegawa M 

PROVIDER: S-EPMC5555208 | biostudies-other | 2017 Aug

REPOSITORIES: biostudies-other

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