Unknown

Dataset Information

0

Role of Y Box Protein-1 in cancer: As potential biomarker and novel therapeutic target.


ABSTRACT: The Y-box binding protein (YB-1) is known to be a multifunctional transcription and translation factor during expression of several proteins. It is a vital oncoprotein that regulates cancer cell progression and proliferation. YB-1 is over-expressed in various human cancers such as breast cancer, colon cancer, lung cancer, gastric cancer, oesophageal cancer and glioblastoma. Nuclear expression of YB-1 is found to be associated with multidrug resistance and cancer cell progression. YB-1 is reported to regulate many cellular signalling pathways in different types of cancer proliferation. Knowledge about nuclear localization and nuclear level expression of YB-1 in different cancers has been correlated with prospective prognosis of cancer. This review discusses the prospects of YB-1 as a potential biomarker as well as therapeutic target in lieu of their role during cancer progression and multidrug resistance.

SUBMITTER: Maurya PK 

PROVIDER: S-EPMC5556654 | biostudies-other | 2017

REPOSITORIES: biostudies-other

Similar Datasets

2023-03-22 | GSE223151 | GEO
| S-EPMC9694279 | biostudies-literature
| S-EPMC3225018 | biostudies-other
| S-EPMC8495272 | biostudies-literature
| S-EPMC6584939 | biostudies-literature
| S-EPMC10815159 | biostudies-literature
2017-02-11 | GSE81828 | GEO
| S-EPMC6246930 | biostudies-literature
| S-EPMC4956265 | biostudies-literature
| S-EPMC6162382 | biostudies-literature