Rapid replacement by non-vaccine pneumococcal serotypes may mitigate the impact of the pneumococcal conjugate vaccine on nasopharyngeal bacterial ecology.

ABSTRACT: There is growing concern that interventions that alter microbial ecology can adversely affect health. We characterised the impact of the seven-valent pneumococcal conjugate vaccine (PCV7) on pneumococcal carriage and the bacterial component of the nasopharyngeal microbiome during infancy. Newborns were recruited into three groups as follows: Group1 (n?=?33) was the control group and comprised infants who received PCV7 after 6 months and came from unvaccinated communities. Group 2 (n?=?30) came from unvaccinated communities and Group 3 (n?=?39) came from vaccinated communities. Both group 2 and 3 received PCV7 at 2, 3 and 4 months. Culture and 16?S rRNA gene sequencing were performed on nasopharyngeal specimens collected at regular intervals from infants. Nasopharyngeal carriage of PCV7 serotypes in Group 1 was significantly higher than in Group 2 and 3 (p?

SUBMITTER: Kwambana-Adams B 

PROVIDER: S-EPMC5557800 | biostudies-other | 2017 Aug

REPOSITORIES: biostudies-other