Ontology highlight
ABSTRACT:
SUBMITTER: Willebrords J
PROVIDER: S-EPMC5557827 | biostudies-other | 2017 Aug
REPOSITORIES: biostudies-other
Willebrords Joost J Cogliati Bruno B Pereira Isabel Veloso Alves IVA da Silva Tereza Cristina TC Crespo Yanguas Sara S Maes Michaël M Govoni Veronica Mollica VM Lima Andressa A Felisbino Daniele Aparecida DA Decrock Elke E Nogueira Marina Sayuri MS de Castro Inar Alves IA Leclercq Isabelle I Leybaert Luc L Rodrigues Robim Marcelino RM Vinken Mathieu M
Scientific reports 20170815 1
While gap junctions mediate intercellular communication and support liver homeostasis, connexin hemichannels are preferentially opened by pathological stimuli, including inflammation and oxidative stress. The latter are essential features of non-alcoholic steatohepatitis. In this study, it was investigated whether connexin32 and connexin43 hemichannels play a role in non-alcoholic steatohepatitis. Mice were fed a choline-deficient high-fat diet or normal diet for 8 weeks. Thereafter, TAT-Gap24 o ...[more]