Ontology highlight
ABSTRACT:
SUBMITTER: Tada H
PROVIDER: S-EPMC5559554 | biostudies-other | 2017 Aug
REPOSITORIES: biostudies-other
Scientific reports 20170816 1
Exposure to a stressful environment early in life can cause psychiatric disorders by disrupting circuit formation. Actin plays central roles in regulating neuronal structure and protein trafficking. We have recently reported that neonatal isolation inactivated ADF/cofilin, the actin depolymerizing factor, resulted in a reduced actin dynamics at spines and an attenuation of synaptic α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor delivery in the juvenile rat medial prefronta ...[more]