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In Vivo Model of Small Intestine.


ABSTRACT: The utilization of human pluripotent stem cells (hPSCs) offers new avenues in the generation of organs and opportunities to understand development and diseases. The hPSC-derived human intestinal organoids (HIOs) provide a new tool to gain insights in small intestinal development, physiology, and associated diseases. Herein, we provide a method for orthotropic transplantation of HIOs in immunocompromised mice. This method highlights the specific steps to successful engraftment and provides insight into the study of bioengineered human small intestine.

SUBMITTER: Mahe MM 

PROVIDER: S-EPMC5559894 | biostudies-other | 2017

REPOSITORIES: biostudies-other

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