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Aging affects human B cell responses.


ABSTRACT: Aging represents a complex remodeling in which both innate and adaptive immunities deteriorate. Age-related changes in humoral immunity are responsible for the reduced vaccine responses observed in elderly individuals. Although T cell alterations play a significant role in age-related humoral immune changes, alterations in B cells also occur. We here provide an overview of age-related changes in B cell markers and functions. Our studies have shown that intrinsic changes in B cells with age contribute to reduced antibody responses such as those to the influenza vaccine.

SUBMITTER: Frasca D 

PROVIDER: S-EPMC5560853 | biostudies-other | 2011 Jun

REPOSITORIES: biostudies-other

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