Functional validation of GPIHBP1 and identification of a functional mutation in GPIHBP1 for milk fat traits in dairy cattle.
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ABSTRACT:
SUBMITTER: Yang J
PROVIDER: S-EPMC5561204 | biostudies-other | 2017 Aug
REPOSITORIES: biostudies-other
Publications
Functional validation of GPIHBP1 and identification of a functional mutation in GPIHBP1 for milk fat traits in dairy cattle.
Yang Jie J Liu Xuan X Wang Dan D Ning Chao C Wang Haifei H Zhang Qin Q Jiang Li L
Scientific reports 20170817 1
In a previous genome-wide association study (GWAS) on milk production traits in a Chinese Holstein population, we revealed that GPIHBP1 is a novel promising candidate gene for milk fat content traits. In this study, we performed over-expression and RNAi experiments on GPIHBP1 in bovine primary mammary epithelial cells. The results showed that the expression of several important milk fat-related genes (LPL, CD36, VLDLR, ACACA and FASN) increased or decreased when the expression of GPIHBP1 was up- ...[more]
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