Dataset Information

Understanding Aging in Place for Older Adults: A Needs Analysis.

ABSTRACT: A goal of many older adults is to remain in their own homes as they age (Beyond 50.05 Survey, 2005). However, a detailed assessment is lacking of the needs of older adults as they age in place. Using focus groups, twenty-six independently living older adults (mean age 78.8 years) from the Atlanta metropolitan area were asked to describe the tasks they perform to maintain their homes, as well as any difficulties they have performing these tasks. Participants described performing a wide range of tasks and focused primarily on physical difficulties. However, participants also reported solutions to manage these difficulties that fell into three broad categories: "Cessation," "Perseverance," and "Compensation." These categories represent classes of opportunities for interventions that may help older adults remain independent in their homes longer. By understanding the nature of home maintenance problems older adults encounter while aging in place, interventions and redesign efforts can be more effective. These data suggest that interventions should start with answering physical issues.

SUBMITTER: Fausset CB

PROVIDER: S-EPMC5561653 | biostudies-other | 2009 Oct

REPOSITORIES: biostudies-other

ACCESS DATA

Similar Datasets

Project description:This study represents the first attempt to perform a profiling analysis of the intergenerational differences in the microRNAs (miRNAs) of melanocytic neoplasms in young adult and older adult groups. Our comparative miRNA profiling provides a novel characterization of the miRnomes of melanocytic neoplasms and melanomas of different age groups and identifies a set of potential diagnostic and potential clinico-pathologic biomarkers that may serve as targets for development of novel miR-based modalities in cancer diagnosis and treatment. An exploratory miRNA analysis of 666 miRs was conducted on formalin fixed and paraffin embedded tissues from 10 adults and 10 young adults including conventional melanoma and melanocytic neoplasms of uncertain biological significance. Age-matched benign melanocytic nevi were used as controls. The comparative profiling was intentionally performed at two extremes of age, i.e., less than 30 years (Mel 30) and greater than 60 years (Mel 60). Primary melanoma in patients greater than 60 years old was characterized by the increased expression of miRs regulating TLR-MyD88-NF-kappaB pathway (hsa-miR -199a), RAS/RAB22A pathway (hsa-miR-204); growth differentiation and migration (hsa-miR337), epithelial mesenchymal transition EMT (let-7b, hsa-miR-10b/10bSTAR(*)), invasion and metastasis (hsa-miR-10b/10bSTAR(*), hsa-miR-30a/e*, hsa-miR-29c*; cellular matrix components (hsa-miR-29c*); invasion-cytokinesis (hsa-miR 99b*) compared to melanoma of younger patients. miR 211 was dramatically downregulated in primary melanoma compared to nevi controls, decreased with increasing age and was among the miRs linked to metastatic processes and potentially targeting the inflammatory receptor CCR10; Primary melanoma in young adult patients was characterized by the increased expression of hsa-miR-449a and decreased expression of hsa-miR146b, hsa-miR 214*. Among the miRs expressed at higher levels in control nevi, compared to adult or young adult melanoma, was hsa-miR 574-3p. Only 2 miRs distinguished adult from young adult-pediatric nevi, hsa-miR374a* and has-miR-566. MiR 30a* appeared to be a strong marker of differentiation in clinical stages I-II adult and pediatric melanoma, and could predict classification of melanoma tissue in the two age groups. Furthermore, lymph node status in the two age groups was characterized by the statistically significant expression of hsa-miR-30a* and hsa-miR-204 (F-test, p-value <0.001).

Dataset Information

Understanding Aging in Place for Older Adults: A Needs Analysis.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure