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Enzymatic self-assembly of an immunoreceptor tyrosine-based inhibitory motif (ITIM).

ABSTRACT: Here we show the first example of an immunoreceptor tyrosine-based inhibitory motif (ITIM), LYYYYL, as well as its enantiomeric or retro-inverso peptide, to self-assemble in water via enzyme-instructed self-assembly. Upon enzymatic dephosphorylation, the phosphohexapeptides become hexapeptides, which self-assemble in water to result in supramolecular hydrogels. This work illustrates a new approach to design bioinspired soft materials from a less explored, but important pool of immunomodulatory peptides.

SUBMITTER: Yamagata N 

PROVIDER: S-EPMC5561744 | biostudies-other | 2017 Jul

REPOSITORIES: biostudies-other

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Enzymatic self-assembly of an immunoreceptor tyrosine-based inhibitory motif (ITIM).

Yamagata Natsuko N   Chen Xiaoyi X   Zhou Jie J   Li Jie J   Du Xuewen X   Xu Bing B  

Organic & biomolecular chemistry 20170704 27

Here we show the first example of an immunoreceptor tyrosine-based inhibitory motif (ITIM), LYYYYL, as well as its enantiomeric or retro-inverso peptide, to self-assemble in water via enzyme-instructed self-assembly. Upon enzymatic dephosphorylation, the phosphohexapeptides become hexapeptides, which self-assemble in water to result in supramolecular hydrogels. This work illustrates a new approach to design bioinspired soft materials from a less explored, but important pool of immunomodulatory p  ...[more]