Evaluation of radiofluorinated carboximidamides as potential IDO-targeted PET tracers for cancer imaging.
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ABSTRACT:
SUBMITTER: Huang X
PROVIDER: S-EPMC5564531 | biostudies-other | 2017 Jul
REPOSITORIES: biostudies-other
Publications
Evaluation of radiofluorinated carboximidamides as potential IDO-targeted PET tracers for cancer imaging.
Huang Xuan X Pan Zhongjie Z Doligalski Michael L ML Xiao Xia X Ruiz Epifanio E Budzevich Mikalai M MM Tian Haibin H
Oncotarget 20170701 29
IDO1 is an enzyme catalyzing the initial and rate-limiting step in the catabolism of tryptophan along the kynurenine pathway. IDO1 expression could suppress immune responses by blocking T-lymphocyte proliferation locally, suggesting a role of IDO in the regulation of immune responses. The goal of this study was to evaluate the potential of radiofluorinated carboximidamides as selective PET radioligands for IDO1. Specific binding correlated with IDO1 expression as measured through in vitro, micro ...[more]
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