Modeling SF3B1 Mutations in Cancer: Advances, Challenges, and Opportunities.
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ABSTRACT: In this issue of Cancer Cell, Obeng et al. identify the consequences of expressing the most common mutation in the spliceosomal gene SF3B1 on hematopoiesis. The knockin mouse model described represents a valuable tool to dissect the effects of SF3B1 mutations on transformation, splicing, and less well-characterized functions of SF3B1.
SUBMITTER: Inoue D
PROVIDER: S-EPMC5569387 | biostudies-other | 2016 Sep
REPOSITORIES: biostudies-other
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