Ontology highlight
ABSTRACT:
SUBMITTER: Das A
PROVIDER: S-EPMC5570084 | biostudies-other | 2017 Jul
REPOSITORIES: biostudies-other
Das Anish A Banday Mahrukh M Fisher Michael A MA Chang Yun-Juan YJ Rosenfeld Jeffrey J Bellofatto Vivian V
Nucleic acids research 20170701 13
A unique feature of RNA polymerase II (RNA pol II) is its long C-terminal extension, called the carboxy-terminal domain (CTD). The well-studied eukaryotes possess a tandemly repeated 7-amino-acid sequence, called the canonical CTD, which orchestrates various steps in mRNA synthesis. Many eukaryotes possess a CTD devoid of repeats, appropriately called a non-canonical CTD, which performs completely unknown functions. Trypanosoma brucei, the etiologic agent of African Sleeping Sickness, deploys an ...[more]