Ontology highlight
ABSTRACT:
SUBMITTER: Ormond L
PROVIDER: S-EPMC5570085 | biostudies-other | 2017 Jul
REPOSITORIES: biostudies-other
Ormond Louise L Liu Ping P Matuszewski Sebastian S Renzette Nicholas N Bank Claudia C Zeldovich Konstantin K Bolon Daniel N DN Kowalik Timothy F TF Finberg Robert W RW Jensen Jeffrey D JD Wang Jennifer P JP
Genome biology and evolution 20170701 7
Influenza virus inflicts a heavy death toll annually and resistance to existing antiviral drugs has generated interest in the development of agents with novel mechanisms of action. Favipiravir is an antiviral drug that acts by increasing the genome-wide mutation rate of influenza A virus (IAV). Potential synergistic benefits of combining oseltamivir and favipiravir have been demonstrated in animal models of influenza, but the population-level effects of combining the drugs are unknown. In order ...[more]