Ontology highlight
ABSTRACT:
SUBMITTER: Insua I
PROVIDER: S-EPMC5570901 | biostudies-other | 2017 Aug
REPOSITORIES: biostudies-other
Insua Ignacio I Zizmare Laimdota L Peacock Anna F A AFA Krachler Anne Marie AM Fernandez-Trillo Francisco F
Scientific reports 20170824 1
Here, we describe the preparation and characterisation of polyion complex (PIC) nanoparticles containing last resort antimicrobial polymyxin B (Pol-B). PIC nanoparticles were prepared with poly(styrene sulphonate) (PSS) as an inert component, across a range of degrees of polymerisation to evaluate the effect that multivalency of this electrolyte has on the stability and antimicrobial activity of these nanoparticles. Our results demonstrate that while nanoparticles prepared with longer polyelectr ...[more]