Ontology highlight
ABSTRACT:
SUBMITTER: Diez JA
PROVIDER: S-EPMC5575201 | biostudies-other | 2017 Aug
REPOSITORIES: biostudies-other
Cell reports 20170801 6
Blood flow regulation in pancreatic islets is critical for function but poorly understood. Here, we establish an in vivo imaging platform in a non-human primate where islets transplanted autologously into the anterior chamber of the eye are monitored non-invasively and longitudinally at single-cell resolution. Engrafted islets were vascularized and innervated and maintained the cytoarchitecture of in situ islets in the pancreas. Blood flow velocity in the engrafted islets was not affected by inc ...[more]