Ontology highlight
ABSTRACT:
SUBMITTER: Kanfer G
PROVIDER: S-EPMC5576903 | biostudies-other | 2017 Sep
REPOSITORIES: biostudies-other
Molecular biology of the cell 20170712 18
Dynamic microtubule ends exert pulling and pushing forces on intracellular membranes and organelles. However, the mechanical linkage of microtubule tips to their cargoes is poorly understood. CENP-F is a nonmotor microtubule-binding protein that participates in microtubule binding at kinetochores and in the mitotic redistribution of the mitochondrial network. CENP-F-driven mitochondrial transport is linked to growing microtubule tips, but the underlying molecular mechanisms are unknown. Here we ...[more]