Ontology highlight
ABSTRACT:
SUBMITTER: Gelinas JF
PROVIDER: S-EPMC5579034 | biostudies-other | 2017 Aug
REPOSITORIES: biostudies-other
Gélinas Jean-François JF Davies Lee A LA Gill Deborah R DR Hyde Stephen C SC
Scientific reports 20170831 1
The development of lentiviral-based therapeutics is challenged by the high cost of current Good Manufacturing Practices (cGMP) production. Lentiviruses are enveloped viruses that capture a portion of the host cell membrane during budding, which then constitutes part of the virus particle. This process might lead to lipid and protein depletion in the cell membrane and affect cell viability. Furthermore, growth in suspension also causes stresses that can affect virus production yields. To assess t ...[more]