Multimerization rules for G-quadruplexes.
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ABSTRACT:
SUBMITTER: Kolesnikova S
PROVIDER: S-EPMC5587800 | biostudies-other | 2017 Sep
REPOSITORIES: biostudies-other
Publications
Multimerization rules for G-quadruplexes.
Kolesnikova Sofia S Hubálek Martin M Bednárová Lucie L Cvacka Josef J Curtis Edward A EA
Nucleic acids research 20170901 15
G-quadruplexes can multimerize under certain conditions, but the sequence requirements of such structures are not well understood. In this study, we investigated the ability of all possible variants of the central tetrad in a monomeric, parallel-strand G-quadruplex to form higher-order structures. Although most of these 256 variants existed primarily as monomers under the conditions of our screen, ∼10% formed dimers or tetramers. These structures could form in a wide range of monovalent and diva ...[more]
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