Ontology highlight
ABSTRACT:
SUBMITTER: Sasaki T
PROVIDER: S-EPMC5595809 | biostudies-other | 2017 Sep
REPOSITORIES: biostudies-other
Sasaki Taeko T Sato Yoshikatsu Y Higashiyama Tetsuya T Sasaki Narie N
Scientific reports 20170912 1
Mitochondrial DNA (mtDNA) is organized in nucleoprotein complexes called mitochondrial nucleoids (mt-nucleoids), which are critical units of mtDNA replication and transmission. In humans, several hundreds of mt-nucleoids exist in a cell. However, how numerous mt-nucleoids are maintained during the cell cycle remains elusive, because cell cycle synchronization procedures affect mtDNA replication. Here, we analyzed regulation of the maintenance of mt-nucleoids in the cell cycle, using a fluorescen ...[more]