Ontology highlight
ABSTRACT:
SUBMITTER: Pasumarthy KK
PROVIDER: S-EPMC5599244 | biostudies-other | 2017 Sep
REPOSITORIES: biostudies-other
Stem cell reports 20170824 3
Human bone marrow stromal cells, or mesenchymal stem cells (BM-MSCs), need expansion prior to use as cell-based therapies in immunological and tissue repair applications. Aging and expansion of BM-MSCs induce epigenetic changes that can impact therapeutic outcomes. By applying sequencing-based methods, we reveal that the breadth of DNA methylation dynamics associated with aging and expansion is greater than previously reported. Methylation changes are enriched at known distal transcription facto ...[more]