Ontology highlight
ABSTRACT:
SUBMITTER: Shintani T
PROVIDER: S-EPMC5599550 | biostudies-other | 2017 Sep
REPOSITORIES: biostudies-other
Scientific reports 20170914 1
Leptin signaling in the hypothalamus plays a crucial role in the regulation of body weight. Leptin resistance, in which leptin signaling is disrupted, is a major obstacle to the improvement of obesity. We herein demonstrated that protein tyrosine phosphatase receptor type J (Ptprj) is expressed in hypothalamic neurons together with leptin receptors, and that PTPRJ negatively regulates leptin signaling by inhibiting the activation of JAK2, the primary tyrosine kinase in leptin signaling, through ...[more]