Ontology highlight
ABSTRACT:
SUBMITTER: Proft J
PROVIDER: S-EPMC5599688 | biostudies-other | 2017 Sep
REPOSITORIES: biostudies-other
Proft Juliane J Rzhepetskyy Yuriy Y Lazniewska Joanna J Zhang Fang-Xiong FX Cain Stuart M SM Snutch Terrance P TP Zamponi Gerald W GW Weiss Norbert N
Scientific reports 20170914 1
Low-voltage-activated T-type calcium channels are essential contributors to the functioning of thalamocortical neurons by supporting burst-firing mode of action potentials. Enhanced T-type calcium conductance has been reported in the Genetic Absence Epilepsy Rat from Strasbourg (GAERS) and proposed to be causally related to the overall development of absence seizure activity. Here, we show that calnexin, an endoplasmic reticulum integral membrane protein, interacts with the III-IV linker region ...[more]