Ontology highlight
ABSTRACT:
SUBMITTER: White NJ
PROVIDER: S-EPMC5608907 | biostudies-other | 2017 Sep
REPOSITORIES: biostudies-other
White N J NJ Watson J J Ashley E A EA
Scientific reports 20170921 1
It has been suggested recently, based on pharmacokinetic-pharmacodynamic modelling exercises, that twice daily dosing of artemisinins increases malaria parasite killing and so could "dramatically enhance and restore drug effectiveness" in artemisinin resistant P. falciparum malaria infections. It was recommended that split dosing should be incorporated into all artemisinin combination regimen designs. To explain why parasite clearance rates were not faster with split dose regimens it was conclud ...[more]