Ontology highlight
ABSTRACT:
SUBMITTER: Sabatini MT
PROVIDER: S-EPMC5609808 | biostudies-other | 2017 Sep
REPOSITORIES: biostudies-other
Science advances 20170922 9
Chemical reactions for the formation of amide bonds are among the most commonly used transformations in organic chemistry, yet they are often highly inefficient. A novel protocol for amidation using a simple borate ester catalyst is reported. The process presents significant improvements over other catalytic amidation methods in terms of efficiency and safety, with an unprecedented substrate scope including functionalized heterocycles and even unprotected amino acids. The method was used to acce ...[more]