Ontology highlight
ABSTRACT:
SUBMITTER: Mayes K
PROVIDER: S-EPMC5610007 | biostudies-other | 2017 Sep
REPOSITORIES: biostudies-other
Mayes Kimberly K Elsayed Zeinab Z Alhazmi Aiman A Waters Michael M Alkhatib Suehyb G SG Roberts Mark M Song Carolyn C Peterson Kristen K Chan Vivian V Ailaney Nikhil N Malapati Pumoli P Blevins Tana T Lisnić Berislav B Dumur Catherine I CI Landry Joseph W JW
Oncotarget 20170512 38
Using syngeneic BALB/c mouse breast cancer models, we show that the chromatin remodeling subunit bromodomain PHD finger transcription factor (BPTF) suppresses natural killer (NK) cell antitumor activity in the tumor microenvironment (TME). In culture, BPTF suppresses direct natural cytotoxicity receptor (NCR) mediated NK cell cytolytic activity to mouse and human cancer cell lines, demonstrating conserved functions. Blocking mouse NCR1 <i>in vivo</i> rescues BPTF KD tumor weights, demonstrating ...[more]