Immunophysical analysis of corneal neovascularization: mechanistic insights and implications for pharmacotherapy.
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ABSTRACT:
SUBMITTER: Azimzade Y
PROVIDER: S-EPMC5610330 | biostudies-other | 2017 Sep
REPOSITORIES: biostudies-other
Publications
Immunophysical analysis of corneal neovascularization: mechanistic insights and implications for pharmacotherapy.
Azimzade Youness Y Hong Jiaxu J Mashaghi Alireza A
Scientific reports 20170922 1
The cornea lacks adaptive immune cells and vasculature under healthy conditions, but is populated by both cell types under pathologic conditions and after transplantation. Here we propose an immunophysical approach to describe postoperative neovascularization in corneal grafts. We develop a simple dynamic model that captures not only the well-established interactions between innate immunity and vascular dynamics but also incorporates the contributions of adaptive immunity to vascular growth. We ...[more]
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