Ontology highlight
ABSTRACT:
SUBMITTER: Andrabi R
PROVIDER: S-EPMC5613947 | biostudies-other | 2017 Sep
REPOSITORIES: biostudies-other
Immunity 20170912 3
Apex broadly neutralizing HIV antibodies (bnAbs) recognize glycans and protein surface close to the 3-fold axis of the envelope (Env) trimer and are among the most potent and broad Abs described. The evolution of apex bnAbs from one donor (CAP256) has been studied in detail and many Abs at different stages of maturation have been described. Using diverse engineering tools, we investigated the involvement of glycan recognition in the development of the CAP256.VRC26 Ab lineage. We found that siali ...[more]