Ontology highlight
ABSTRACT:
SUBMITTER: Li PD
PROVIDER: S-EPMC5617486 | biostudies-other | 2017 Sep
REPOSITORIES: biostudies-other
Oncotarget 20170701 37
Glutathione is the major intracellular anti-oxidant against reactive oxygen species and serves as a detoxification essential. The anti-diabetic drug metformin has been showed to exert anti-tumor activity via modulation of redox homeostasis. In this study, we provided evidence that metformin inhibits proliferation and induces apoptosis of esophageal squamous cancer cells. Importantly, we found that metformin acts as pro-oxidant via depletion of intracellular glutathione. Co-treatment with metform ...[more]