Ontology highlight
ABSTRACT:
SUBMITTER: Dokouhaki M
PROVIDER: S-EPMC5618249 | biostudies-other | 2017 Sep
REPOSITORIES: biostudies-other
Dokouhaki Mina M Prime Emma L EL Hung Andrew A Qiao Greg G GG Day Li L Gras Sally L SL
Biomolecules 20170919 3
Chaplin F (Chp F) is a secreted surface-active peptide involved in the aerial growth of <i>Streptomyces</i>. While Chp E demonstrates a pH-responsive surface activity, the relationship between Chp F structure, function and the effect of solution pH is unknown. Chp F peptides were found to self-assemble into amyloid fibrils at acidic pH (3.0 or the isoelectric point (pI) of 4.2), with ~99% of peptides converted into insoluble fibrils. In contrast, Chp F formed short assemblies containing a mixtur ...[more]