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Self-Assembly of Human Serum Albumin: A Simplex Phenomenon.

ABSTRACT: Spontaneous self-assemblies of biomolecules can generate geometrical patterns. Our findings provide an insight into the mechanism of self-assembled ring pattern generation by human serum albumin (HSA). The self-assembly is a process guided by kinetic and thermodynamic parameters. The generated protein ring patterns display a behavior which is geometrically related to a n-simplex model and is explained through thermodynamics and chemical kinetics.

SUBMITTER: Thakur G 

PROVIDER: S-EPMC5618250 | biostudies-other | 2017 Sep

REPOSITORIES: biostudies-other

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Self-Assembly of Human Serum Albumin: A Simplex Phenomenon.

Thakur Garima G   Prashanthi Kovur K   Jiang Keren K   Thundat Thomas T  

Biomolecules 20170920 3

Spontaneous self-assemblies of biomolecules can generate geometrical patterns. Our findings provide an insight into the mechanism of self-assembled ring pattern generation by human serum albumin (HSA). The self-assembly is a process guided by kinetic and thermodynamic parameters. The generated protein ring patterns display a behavior which is geometrically related to a <i>n</i>-simplex model and is explained through thermodynamics and chemical kinetics. ...[more]