Ontology highlight
ABSTRACT:
SUBMITTER: Akimova T
PROVIDER: S-EPMC5621877 | biostudies-other | 2017 Aug
REPOSITORIES: biostudies-other
Akimova Tatiana T Zhang Tianyi T Negorev Dmitri D Singhal Sunil S Stadanlick Jason J Rao Abhishek A Annunziata Michael M Levine Matthew H MH Beier Ulf H UH Diamond Joshua M JM Christie Jason D JD Albelda Steven M SM Eruslanov Evgeniy B EB Hancock Wayne W WW
JCI insight 20170817 16
Experimental data indicate that FOXP3+ Tregs can markedly curtail host antitumor immune responses, but the properties of human intratumoral Tregs are still largely unknown, in part due to significant methodologic problems. We studied the phenotypic, functional, epigenetic, and transcriptional features of Tregs in 92 patients with non-small-cell lung cancer, comparing the features of Tregs within tumors versus corresponding blood, lung, and lymph node samples. Intratumoral Treg numbers and suppre ...[more]