Snail suppresses cellular senescence and promotes fibroblast-led cancer cell invasion.
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ABSTRACT:
SUBMITTER: Furuya S
PROVIDER: S-EPMC5623692 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
Publications
Snail suppresses cellular senescence and promotes fibroblast-led cancer cell invasion.
Furuya Satoshi S Endo Kaori K Takahashi Akiko A Miyazawa Keiji K Saitoh Masao M
FEBS open bio 20170911 10
Snail, a zinc finger transcription factor, induces an epithelial-mesenchymal transition (EMT) in various cancer and epithelial cells. We investigated the function of Snail (<i>SNAI1</i>) by downregulating its expression with short interfering RNA (siRNA). Suppression of Snail expression induced cellular senescence in several cancer cells and in normal fibroblast IMR90 cells. Cancer progression is facilitated by fibroblasts, so-called fibroblast-led cancer cell invasion. Snail-silenced cancer cel ...[more]
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